Transport of fluorescent bile acids by the isolated perfused rat liver: Kinetics, sequestration, and mobilization
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چکیده
منابع مشابه
SEQUESTRATION OF LEUKOCYTES BY THE ISOLATED PERFUSED RAT LUNG
The sequestration of rat leukocytes and bone marrow cells by the lung vasculature was studied using an isolated perfused rat lung preparation. The passage of latex particles of 7.6 µm in diameter and non-hematopoietic cells through the lung blood vessels was also studied. Leukocytes and bone marrow cells were reversibly sequestered from circulation, whereas, latex particles and non-hematop...
متن کاملUptake of bile acids by perfused rat liver
REICHEN, J~RG, AND GUSTAV PAUMGARTNER. Uptake of bile acids by perfused rat liver. Am. J. Physiol. 231(3): 734742. 1976. -The uptake of W-labeled cholic, taurocholic, and chenodeoxycholic acid by the perfused rat liver was studied to characterize the mechanism responsible for hepatic uptake of bile acids. A rapid-injection multiple indicator-dilution technique and the three-compartment model of...
متن کاملsequestration of leukocytes by the isolated perfused rat lung
the sequestration of rat leukocytes and bone marrow cells by the lung vasculature was studied using an isolated perfused rat lung preparation. the passage of latex particles of 7.6 µm in diameter and non-hematopoietic cells through the lung blood vessels was also studied. leukocytes and bone marrow cells were reversibly sequestered from circulation, whereas, latex particles and non-hematopoieti...
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Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
متن کاملThe isolated perfused rat liver.
The disposition of mefloquine has been investigated in the isolated perfused rat liver (IPRL) preparation after the administration of [C]mefloquine HCI (3.8 mg, 4 1 Ci, quinoline ring labeled). Mefloquine underwent avid hepatic uptake within 10 min of dosing. Also at this point, hepatic oxygen consumption was reduced markedly in four of the six IPRL preparations, but was restored completely by ...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1998
ISSN: 0270-9139
DOI: 10.1002/hep.510280231